Scattered Mosaic Rendering Using Unit Images

An image mosaic method that can be used when creating advertisements or posters is proposed in this study. Mosaic is a method that expresses an entire image using an arbitrary number of cells. Photomosaic generates new images using a combination of photos. In this paper, we propose a new mosaic algorithm that generates an abstract artistic mosaic image by filling a region that is divided by a boundary using a unit image, which is an image that only has a shape and no allocated color. A unit image can be changed diversely through rotation or shifting, and the corresponding region is filled by using the gradient direction and edge information of the input image. For this, we extract and use information from input image such as color, edge and gradient. In result we can generate various abstractive images which can be used in advertisement and multimedia contents market

A New Model for Raf Kinase Inhibitory Protein Induced Chemotherapeutic Resistance

Therapeutic resistance remains the most challenging aspect of treating cancer. Raf kinase inhibitory protein (RKIP) emerged as a molecule capable of sensitizing cancerous cells to radio- and chemotherapy. Moreover, this small evolutionary conserved molecule, endows significant resistance to cancer therapy when its expression is reduced or lost. RKIP has been shown to inhibit the Raf-MEK-ERK, NFκB, GRK and activate the GSK3β signaling pathways. Inhibition of Raf-MEK-ERK and NFκB remains the most prominent pathways implicated in the sensitization of cells to therapeutic drugs. Our purpose was to identify a possible link between RKIP-KEAP 1-NRF2 and drug resistance. To that end, RKIP-KEAP 1 association was tested in human colorectal cancer tissues using immunohistochemistry. RKIP miRNA silencing and its inducible overexpression were employed in HEK-293 immortalized cells, HT29 and HCT116 colon cancer cell lines to further investigate our aim. We show that RKIP enhanced Kelch-like ECH-associated protein1 (KEAP 1) stability in colorectal cancer tissues and HT29 CRC cell line. RKIP silencing in immortalized HEK-293 cells (termed HEK-499) correlated significantly with KEAP 1 protein degradation and subsequent NRF2 addiction in these cells. Moreover, RKIP depletion in HEK-499, compared to control cells, bestowed resistance to supra physiological levels of H2O2 and Cisplatin possibly by upregulating NF-E2-related nuclear factor 2 (NRF2) responsive genes. Similarly, we observed a direct correlation between the extent of apoptosis, after treatment with Adriamycin, and the expression levels of RKIP/KEAP 1 in HT29 but not in HCT116 CRC cells. Our data illuminate, for the first time, the NRF2-KEAP 1 pathway as a possible target for personalized therapeutic intervention in RKIP depleted cancers

Simulation of Urban Growth and Urban Living Environment with Release of the Green Belt

Green belts in developing or developed countries have been released because city-center development has reached a saturation point, and the strict protections and restrictions within green belts has led to an increase in opposition from local residents and property owners. However, green belt release has led to urban growth within the associated regions and cities, resulting in an increase in the temperature and the accumulation of pollutants in the atmosphere. We intend to prove quantitatively the effect of the release of green belts at the local level based on the interactions among land cover, climate, and air quality and to provide information for policy decisions accordingly. Our simulation results show that the urban areas of Jeju and Chuncheon, in South Korea, where green belts have been completely released, will increase by up to 21.83% by 2025 and 123.93% by 2020, respectively, compared to areas that have retained green belts. The simulations also show that the surface temperature within the released region of Jeju and Chuncheon will increase by up to 0.83% by 2025 and 0.03% by 2020, respectively. The average atmospheric concentrations within the released region of Jeju and Chuncheon were modelled to increase by up to 256.93% by 2025 and 337.29% by 2020, respectively

High-Voltage-Driven Surface Structuring and Electrochemical Stabilization of Ni-Rich Layered Cathode Materials for Li Rechargeable Batteries

Layered lithium-nickel-cobalt-manganese oxide (NCM) materials have emerged as promising alternative cathode materials owing to their high energy density and electrochemical stability. Although high reversible capacity has been achieved for Ni-rich NCM materials when charged beyond 4.2 V versus Li+/Li, full lithium utilization is hindered by the pronounced structural degradation and electrolyte decomposition. Herein, the unexpected realization of sustained working voltage as well as improved electrochemical performance upon electrochemical cycling at a high operating voltage of 4.9 V in the Ni-rich NCM LiNi0.895Co0.085Mn0.02O2 is presented. The improved electrochemical performance at a high working voltage at 4.9 V is attributed to the removal of the resistive Ni2+O rock-salt surface layer, which stabilizes the voltage profile and improves retention of the energy density during electrochemical cycling. The manifestation of the layered Ni2+O rock-salt phase along with the structural evolution related to the metal dissolution are probed using in situ X-ray diffraction, neutron diffraction, transmission electron microscopy, and X-ray absorption spectroscopy. The findings help unravel the structural complexities associated with high working voltages and offer insight for the design of advanced battery materials, enabling the realization of fully reversible lithium extraction in Ni-rich NCM materials